Search results for "Bone marrow mononuclear cells"

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The comparison of knee osteoarthritis treatment with single-dose bone marrow-derived mononuclear cells vs. hyaluronic acid injections

2017

Objective: The aim of this study was to compare treatment methods of the knee joint degenerative osteoarthritis, using autologous bone marrow-derived mononuclear cells and hyaluronic acid injections and observe prevalence of adverse effects in both groups. Materials and methods: A prospective randomized controlled clinical trial was carried out. The analysis of pain and changes in osteoarthritis symptoms after a single intra-articular bone marrow-derived mononuclear cell injection into the knee joint in the Kellgren– Lawrence stage II–III osteoarthritis during the 12-month period were performed. The results were compared with the control group treated routinely by hyaluronic acid injections…

Malemusculoskeletal diseasesmedicine.medical_specialtySodium hyaluronateKnee osteoarthritis; Bone marrow mononuclear cells; CartilageUrologyOsteoarthritisKnee JointPeripheral blood mononuclear cellMonocytesInjections Intra-Articular03 medical and health scienceschemistry.chemical_compound0302 clinical medicineStatistical significanceHyaluronic acidHumansMedicineHyaluronic AcidAdverse effectAgedBone Marrow TransplantationMedicine(all)030203 arthritis & rheumatology030222 orthopedicslcsh:R5-920business.industryMiddle AgedOsteoarthritis Kneemedicine.diseaseTreatment Outcomemedicine.anatomical_structureCartilagechemistryAutomotive EngineeringBone marrow mononuclear cellsFemaleBone marrowKnee osteoarthritisbusinesslcsh:Medicine (General)Medicina
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New Modalities in Knee Osteoarthritis Treatment Using Autologous Bone Marrow-Derived Mononuclear Cells

2018

Abstract The clinical effects on knee osteoarthritis (OA) symptoms and tissue structure were evaluated after bone marrow-derived mononuclear cell intraarticular injection. A group of 32 patients with 34 knee joints in stage II–III osteoarthritis were treated by intraarticular injection of mononuclear cell suspension. Clinical results were obtained by KOOS (Knee Osteoarthritis Outcome Score) and KSS (Knee Society Score) scores during a 12 months follow-up period. Radiological evaluation was performed using magnetic resonance imaging. A comparison with a control group of 28 patients treated with routinely used three hyaluronic acid intra-articular injections was made. No adverse effects were …

musculoskeletal diseasesPathologymedicine.medical_specialtymesenchymal stem cellsMultidisciplinaryModalitiesGeneral interestChemistryScienceQVirulenceOsteoarthritismedicine.disease_causeAutologous bonemedicine.diseasePeripheral blood mononuclear cellknee osteoarthritisMicrobiologyAntibiotic resistanceregenerative therapyhyaluronic acidmedicinebone marrow mononuclear cellsEscherichia coliGeneProceedings of the Latvian Academy of Sciences. Section B, Natural Sciences
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